In a ruling on Friday the Court nullified the elections of both Senators representing their constituencies in the State.
Oduah was a former Aviation Minister who resigned her position to pursue her political ambition while Mr Uba was a former Special Adviser to former President Olusegun Obasanjo on Domestic Affairs.
The Independent National Electoral Commission had declared them winners after the Senatorial election held last year.
All the Senators from Anambra State, including Mrs Ekwunife, emerged on the platform of the Peoples Democratic Party (PDP).
The apex court in its ruling also re-affirmed the chairmanship of Ejike Oguebego as the authentic State Chairman of the PDP in Anambra State.
The Supreme Court also declared the list of candidates submitted by the other faction illegal.
Mr Oguebego had sued on behalf of themselves and others including Mr Chris Uba, who is the Anambra South Senatorial Zone candidate for the apex court to determine who were the legal and validly nominated candidates of the party to stand for the last general elections for the party in the state.
On December 7, the Court of Appeal in Enugu nullified the election of Uche Ekwunife, as the Senator representing Anambra Central Senatorial District.
The court consequently ordered a fresh election within 90 days.
After the Appeal Court’s order, Mrs Ekwunife defected to the All Progressives Congress (APC), with hopes of securing the ticket, after Senator Chris Ngige of the APC who also vied for the position had been appointed Minister.
Anambra Central Senatorial district is regarded as one of the most keenly contested in the country having a former Governor Chris Ngige, the National Chairman of the All Progressives Grand Alliance (APGA), Chief Victor Umeh and of course Mrs Ekwunife.